GeneToBe News
January 2020
GeneToBe forms LLC
December 03, 2020
Advancing Gene Editing With New CRISPR/Cas9 Variant Read News+
December 04, 2020
Advancing Gene Editing With New CRISPR/Cas9 Variant Read News+
Cas9 modification can improve efficiency of gene editing Read News+
CRISPR Medicine News Read News+
X-MOL Read Article+
January 14, 2021
CRISPR: three new developments in the world of gene editing Read News+
February 01, 2021
Dr. Michael Iannuzzi joins team as Chief Medical Officer Read More+
August 2021
GeneToBe licenses patents for a Cystic Fibrosis treatment technology from University of Michigan Read News+
Publications
Hirai et al. The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay. Molecular Therapy: Methods & Clinical Development. 2022 March (24). Read Article+
Yang et al. Effective gene targeting in rabbits using RNA-guided Cas9 nucleases. J Mol Cell Biol. 2014 Feb;6(1):97-9. Read Article+
Ma et al. CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation. J Vis Exp.2019 Jun 20;(148). Read Article+
Ruan et al. Efficient Gene Editing at Major CFTR Mutation Loci. Mol Ther Nucleic Acids.2019 Jun 7;16:73-81. Read Article+
Yang et al. Generation of Rabbit Models by Gene Editing Nucleases.MethodsMol Biol. 2019;1874:327-345. Read Article+
Ma et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun.2020,11(1):6082. Read Article+
Song et al. Genome engineering technologies in rabbits. J Biomed Res. 2020 Jun 12:1-13. doi: 10.7555/JBR.34.20190133. Read Article+
Yang et al. Production of CFTR-ΔF508 Rabbits. Front Genet.2021 Jan 22;11:627666. Read Article+
Xu et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight.2021 Jan 11;6(1):e139813. Read Article+
Xu et al. Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research. Front Genet. 2021 Jan 28;12:642444. Read Article+
Patent Estate
U.S. Serial No. 62/895,800
U.S. Serial No. 62/948,660
U.S. Serial No. 63/152,727
PCT application PCT/US2020/049369
Helpful Resources
CRISPR/Cas9 Technology
https://www.synthego.com/blog/gene-editing-nobel-prize#charpentier-and-doudna-win-nobel-prize-in-chemistry-for-developing-crispr-technology
https://www.nature.com/collections/txhdfslxzh/videos
Cystic Fibrosis Foundation
Cystic Fibrosis Gene Editing
https://www.youtube.com/watch?v=nWj7Be6PSS4
Foundation for Fighting Blindness
https://www.fightingblindness.org
Usher III Initiative
Usher Syndrome Coalition
https://www.usher-syndrome.org/
Usher Syndrome (U.S. National Library of Medicine)
https://ghr.nlm.nih.gov/condition/usher-syndrome
What is Gene Therapy? (U.S. National Library of Medicine)
https://ghr.nlm.nih.gov/primer/therapy/genetherapy